Department of Oncology, Bajcsy-Zsilinszky Municipal Hospital, Budapest, Hungary.
Nutr Cancer. 2009;61(6):891-9. doi: 10.1080/01635580903285114.
Many healthy foods are derived from wheat germ. The molecular composition of these products, however, greatly differs as shown by normal-phase HPLC-mass spectrometry analysis; thus, experimental data obtained by one of them is not necessarily true for the other. Avemar is a nontoxic wheat germ extract registered as a special nutriment for cancer patients in Hungary. It shows potent anticancer activity on cell lines by deeply interfering with glucose metabolism and affecting expressions of several kinases. In in vivo experimental models, Avemar is also effective by enhancing the activity of the immune system such as stimulating NK cell activity (by reducing MHC I molecule expression), enhancing TNF secretion of the macrophages, increasing ICAM 1 molecule expression on the vascular endothelial cells. All of these lead to apoptosis of tumor cells. The wide range of biological activity of Avemar probably cannot be explained by only one active ingredient. Since there are numerous experimental data and the clinical benefit repeatedly confirmed Avemar can be one of the most potent and best researched food supplements available for cancer patients.
许多健康食品都源自小麦胚芽。然而，通过正相高效液相色谱-质谱分析可以看出，这些产品的分子组成有很大的不同；因此，从其中一种产品获得的实验数据不一定适用于其他产品。Avemar 是一种无毒的小麦胚芽提取物，在匈牙利被注册为癌症患者的特殊营养品。它通过深度干扰葡萄糖代谢和影响几种激酶的表达，在细胞系上显示出强大的抗癌活性。在体内实验模型中，Avemar 还通过增强免疫系统的活性而有效，例如通过降低 MHC I 分子的表达来刺激 NK 细胞的活性，增强巨噬细胞的 TNF 分泌，增加血管内皮细胞上的 ICAM 1 分子的表达。所有这些都导致肿瘤细胞的凋亡。Avemar 广泛的生物学活性可能不能仅用一种活性成分来解释。由于有大量的实验数据和反复证实的临床益处，Avemar 可以作为最有效和研究最多的癌症患者可用的食品补充剂之一。
