Pecoraro Felice, Gloekler Steffen, Mader Caecilia E, Roos Malgorzata, Chaykovska Lyubov, Veith Frank J, Cayne Neal S, Mangialardi Nicola, Neff Thomas, Lachat Mario
Clinic for Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland.
Vascluar Surgery Unit, University Hospital "P. Giaccone", Via Liborio Giuffrè, 5, 90100, Palermo, Italy.
Updates Surg. 2018 Mar;70(1):129-136. doi: 10.1007/s13304-017-0488-y. Epub 2017 Sep 14.
The background of this paper is to report the mortality at 30 and 90 days and at mean follow-up after open abdominal aortic aneurysms (AAA) emergent repair and to identify predictive risk factors for 30- and 90-day mortality. Between 1997 and 2002, 104 patients underwent emergent AAA open surgery. Symptomatic and ruptured AAAs were observed, respectively, in 21 and 79% of cases. Mean patient age was 70 (SD 9.2) years. Mean aneurysm maximal diameter was 7.4 (SD 1.6) cm. Primary endpoints were 30- and 90-day mortality. Significant mortality-related risk factor identification was the secondary endpoint. Open repair trend and its related perioperative mortality with a per-year analysis and a correlation subanalysis to identify predictive mortality factor were performed. Mean follow-up time was 23 (SD 23) months. Overall, 30-day mortality was 30%. Significant mortality-related risk factors were the use of computed tomography (CT) as a preoperative diagnostic tool, AAA rupture, preoperative shock, intraoperative cardiopulmonary resuscitation (CPR), use of aortic balloon occlusion, intraoperative massive blood transfusion (MBT), and development of abdominal compartment syndrome (ACS). Previous abdominal surgery was identified as a protective risk factor. The mortality rate at 90 days was 44%. Significant mortality-related risk factors were AAA rupture, aortocaval fistula, peripheral artery disease (PAD), preoperative shock, CPR, MBT, and ACS. The mortality rate at follow-up was 45%. Correlation analysis showed that MBT, shock, and ACS are the most relevant predictive mortality factor at 30 and 90 days. During the transition period from open to endovascular repair, open repair mortality outcomes remained comparable with other contemporary data despite a selection bias for higher risk patients. MBT, shock, and ACS are the most pronounced predictive mortality risk factors.
本文的背景是报告腹主动脉瘤(AAA)急诊开放修复术后30天、90天及平均随访期的死亡率,并确定30天和90天死亡率的预测风险因素。1997年至2002年期间,104例患者接受了AAA急诊开放手术。有症状和破裂的AAA分别占病例的21%和79%。患者平均年龄为70(标准差9.2)岁。动脉瘤平均最大直径为7.4(标准差1.6)cm。主要终点是30天和90天死亡率。确定与死亡率显著相关的风险因素是次要终点。采用逐年分析和相关性亚分析进行开放修复趋势及其相关围手术期死亡率分析,以确定预测死亡因素。平均随访时间为23(标准差23)个月。总体而言,30天死亡率为30%。与死亡率显著相关的风险因素包括使用计算机断层扫描(CT)作为术前诊断工具、AAA破裂、术前休克、术中心肺复苏(CPR)、使用主动脉球囊阻断、术中大量输血(MBT)以及腹腔间隔室综合征(ACS)的发生。既往腹部手术被确定为保护性风险因素。90天死亡率为44%。与死亡率显著相关的风险因素包括AAA破裂、主动脉腔静脉瘘、外周动脉疾病(PAD)、术前休克、CPR、MBT和ACS。随访期死亡率为45%。相关性分析表明,MBT、休克和ACS是30天和90天最相关的预测死亡因素。在从开放修复向血管腔内修复的过渡时期,尽管对高风险患者存在选择偏倚,但开放修复的死亡率结果仍与其他当代数据相当。MBT、休克和ACS是最显著的预测死亡风险因素。