通过多组分反应实现新型双螺吡咯烷双氧化吲哚衍生物的区域和立体选择性合成。
Regio- and stereoselective synthesis of novel dispiropyrrolidine bisoxindole derivatives via multicomponent reactions.
作者信息
Liu Hai, Dou Guolan, Shi Daqing
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P R China.
出版信息
J Comb Chem. 2010 Mar 8;12(2):292-4. doi: 10.1021/cc900195t.
A convenient and efficient method for the synthesis of novel dispiropyrrolidine bisoxindole derivatives by 1,3-dipolar cycloaddition reaction of azomethine ylides has been developed. The synthesis was achieved by using a one-pot multicomponent procedure. The features of this procedure were characterized by the following: mild reaction conditions, high yields, high regio- and stereoselectivity, one-pot procedure, and operational simplicity.
已经开发出一种通过甲亚胺叶立德的1,3-偶极环加成反应合成新型双螺吡咯烷双氧化吲哚衍生物的便捷高效方法。该合成通过一锅多组分程序实现。该程序的特点如下：反应条件温和、产率高、区域和立体选择性高、一锅法程序以及操作简便。
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