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通过三组分 1,3-偶极环加成反应简便合成功能化双螺环氧化吲哚衍生物。

A facile synthesis of functionalized dispirooxindole derivatives via a three-component 1,3-dipolar cycloaddition reaction.

机构信息

State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.

出版信息

Molecules. 2013 May 3;18(5):5142-54. doi: 10.3390/molecules18055142.

DOI:10.3390/molecules18055142
PMID:23644979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6270352/
Abstract

An efficient synthesis of novel dispirooxindoles has been achieved through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylideneimidazolidine-2,4-dione. The improved procedure features mild reaction conditions, high yields, high diastereoselectivities, a one-pot procedure and operational simplicity.

摘要

通过靛红与α-氨基酸的脱羧缩合原位生成亚胺叶立德与偶极子 5-亚苄基咪唑烷-2,4-二酮的三组分 1,3-偶极环加成反应，高效合成了新型双螺环氧化吲哚。改进后的方法具有反应条件温和、产率高、非对映选择性高、一锅法和操作简单的特点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb67/6270352/5207e99aa1a8/molecules-18-05142-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb67/6270352/f51fc5e0a76e/molecules-18-05142-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb67/6270352/cf026af07136/molecules-18-05142-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb67/6270352/e90ec9704f4a/molecules-18-05142-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb67/6270352/3b5ac81bb2cd/molecules-18-05142-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb67/6270352/5207e99aa1a8/molecules-18-05142-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb67/6270352/f51fc5e0a76e/molecules-18-05142-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb67/6270352/cf026af07136/molecules-18-05142-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb67/6270352/e90ec9704f4a/molecules-18-05142-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb67/6270352/3b5ac81bb2cd/molecules-18-05142-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb67/6270352/5207e99aa1a8/molecules-18-05142-g005.jpg

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