Cancer Control and Population Sciences Program, University of Puerto Rico Comprehensive Cancer Center, San Juan, Puerto Rico.
Metab Syndr Relat Disord. 2010 Jun;8(3):235-42. doi: 10.1089/met.2009.0076.
The metabolic syndrome is an interaction of risk factors that may lead to cardiovascular disease and type 2 diabetes.
Given the need for data in Puerto Rico, this cross-sectional study aimed to determine the association between demographic, lifestyles, and reproductive characteristics and the metabolic syndrome among a sample of women (N = 564) in the San Juan Metropolitan Area. The metabolic syndrome was defined based on the revised National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria.
In multivariate logistic regression models, women aged 40-59 and 60-79 years were 3.03 [95% confidence interval (CI), 1.70, 5.40] and 7.05 (95% CI, 3.69, 13.49) times more likely, respectively, to have the metabolic syndrome as compared to those aged 21-39 years. A dose-response relationship was also observed between body mass index (BMI) and metabolic syndrome. Physical activity reduced the odds for metabolic syndrome [prevalence odds ratios (POR) = 0.64; 95% CI, 0.41, 1.01]; however, this association was marginally significant (P = 0.05). Among reproductive characteristics, only women who had a history of gestational diabetes (GDM) were 2.14 (95% CI, 1.02, 4.51) times more likely to have metabolic syndrome.
Consistent with previous studies, increased age and BMI, physical inactivity, and GDM are associated with the metabolic syndrome in this population. This information is relevant for the development of preventive interventions for the metabolic syndrome.
代谢综合征是一系列可能导致心血管疾病和 2 型糖尿病的危险因素相互作用的结果。
鉴于波多黎各需要相关数据，本横断面研究旨在确定圣胡安大都市区女性样本（N=564）中人口统计学、生活方式和生殖特征与代谢综合征之间的关联。代谢综合征的定义基于修订后的国家胆固醇教育计划成人治疗专家组第三版（NCEP ATP III）标准。
在多变量逻辑回归模型中，40-59 岁和 60-79 岁的女性患有代谢综合征的可能性分别是 21-39 岁女性的 3.03 倍（95%置信区间[CI]，1.70，5.40）和 7.05 倍（95% CI，3.69，13.49）。还观察到体重指数（BMI）与代谢综合征之间存在剂量反应关系。身体活动降低了代谢综合征的可能性[患病优势比（POR）=0.64；95% CI，0.41，1.01]；然而，这种关联具有边缘显著性（P=0.05）。在生殖特征中，只有患有妊娠糖尿病（GDM）的女性患有代谢综合征的可能性增加 2.14 倍（95% CI，1.02，4.51）。
与先前的研究一致，年龄和 BMI 增加、身体活动不足和 GDM 与该人群的代谢综合征相关。这些信息对于代谢综合征预防干预措施的制定具有重要意义。
