Department of Internal Medicine, Section of Endocrinology and Metabolism, Yeditepe University Medical Faculty, Istanbul, Turkey.
Metab Syndr Relat Disord. 2010 Jun;8(3):229-34. doi: 10.1089/met.2009.0080.
Epicardial adipose tissue has shown to be related to cardiovascular risk. The aim of this study is to investigate the relationship between epicardial adiposity and endothelial function in metabolic syndrome.
Fifty patients with metabolic syndrome were recruited. Anthropometric measurements, fasting blood glucose, insulin, lipid profile, high-sensitivity C-reactive protein (hsCRP), fibrinogen, apolipoprotein A (Apo A), Apo B1, and lipoprotein (a) [Lp(a)] were determined. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Epicardial fat thickness was measured via two-dimensional M-mode echocardiography. Endothelial function was assessed as flow-mediated dilatation at the brachial artery.
Epicardial fat tissue thickness was shown to be correlated negatively with FMD and positively with age, diastolic blood pressure, hsCRP, fibrinogen, HOMA-IR, and lipid parameters. Multiple regression analysis showed epicardial fat tissue thickness to be an independent factor influencing the endothelial function.
Epicardial fat tissue may be a useful parameter in the assessment of patients with metabolic syndrome.
心外膜脂肪组织与心血管风险相关。本研究旨在探讨代谢综合征中心外膜脂肪堆积与内皮功能的关系。
招募了 50 名代谢综合征患者。测量了人体测量学指标、空腹血糖、胰岛素、血脂谱、高敏 C 反应蛋白（hsCRP）、纤维蛋白原、载脂蛋白 A（Apo A）、载脂蛋白 B1 和脂蛋白（a）[Lp（a）]。计算了胰岛素抵抗的稳态模型评估（HOMA-IR）。通过二维 M 型超声心动图测量心外膜脂肪厚度。肱动脉血流介导的扩张（FMD）用于评估内皮功能。
心外膜脂肪组织厚度与 FMD 呈负相关，与年龄、舒张压、hsCRP、纤维蛋白原、HOMA-IR 和血脂参数呈正相关。多元回归分析显示，心外膜脂肪组织厚度是影响内皮功能的独立因素。
心外膜脂肪组织可能是评估代谢综合征患者的有用参数。
