妊娠糖尿病患者的视黄醇结合蛋白 4。
Retinol-binding protein 4 in patients with gestational diabetes mellitus.
机构信息
Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
出版信息
J Womens Health (Larchmt). 2010 Mar;19(3):517-21. doi: 10.1089/jwh.2009.1615.
OBJECTIVE
It is still unknown if serum retinol-binding protein 4 (RBP4) relates to metabolic control and the occurrence of gestational diabetes mellitus (GDM). We studied RBP4 levels in patients with insulin-treated GDM and healthy pregnant women twice during pregnancy.
METHODS
Sixty-three women with GDM and 38 healthy pregnant women were included. Serum RBP4 levels were measured at 24-28 weeks of gestation and 8 weeks later. Patients with GDM were treated with insulin.
RESULTS
Serum RBP4 levels increased significantly between the two measurements in patients with GDM (p = 0.03). In patients with GDM, RBP4 concentrations at 33 weeks of gestation correlated positively with mean blood glucose, hemoglobin A1c values, and cord blood insulin values right after delivery. Regression analyses showed that the diagnosis of GDM (p = 0.04) and hemoglobin A1c levels (p < 0.001) were related to RBP4 levels at 33 weeks of gestation.
CONCLUSIONS
Serum RBP4 levels increase during pregnancy in patients with insulin-treated GDM.
目的
血清视黄醇结合蛋白 4（RBP4）是否与代谢控制和妊娠糖尿病（GDM）的发生有关仍不清楚。我们在妊娠期间两次研究了接受胰岛素治疗的 GDM 患者和健康孕妇的 RBP4 水平。
方法
纳入 63 例 GDM 患者和 38 例健康孕妇。在妊娠 24-28 周和 8 周后测量血清 RBP4 水平。GDM 患者接受胰岛素治疗。
结果
GDM 患者两次测量的血清 RBP4 水平均显著升高（p=0.03）。在 GDM 患者中，妊娠 33 周时的 RBP4 浓度与分娩后即刻的平均血糖、糖化血红蛋白值和脐血胰岛素值呈正相关。回归分析显示，GDM 的诊断（p=0.04）和糖化血红蛋白水平（p<0.001）与妊娠 33 周时的 RBP4 水平相关。
结论
接受胰岛素治疗的 GDM 患者在妊娠期间血清 RBP4 水平升高。
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