Obstetrical Department, Women's Hospital, School of Medicine, Zhejiang University , Hangzhou , China.
Gynecol Endocrinol. 2014 Feb;30(2):161-4. doi: 10.3109/09513590.2013.871515. Epub 2014 Jan 7.
The role of retinol binding protein 4 (RBP4) in insulin resistance was recently identified. Our study investigated the correlation between RBP4 levels with lipid and glucose metabolism in a case-control study of women with gestational diabetes mellitus (GDM). Between May 2008 and May 2010, 70 pregnant women (24-28 weeks gestation) were recruited, including 35 women with GDM and 35 healthy controls. Blood samples were collected prior to and after oral glucose tolerance tests (OGTT) to detect serum RBP4, insulin, glycated hemoglobin, triglyceride (TG) and total cholesterol (TC) levels; the insulin resistance index (HOMA-IR) was calculated. Serum RBP4 levels in the GDM group were significantly higher than the control group (22.9 ± 3.09 µg/ml versus 17.9 ± 3.91 µg/ml; p < 0.01). Insulin, TC and TG levels in the GDM group and the control group were all significantly higher than the control group (p < 0.05). Serum RBP4 levels in the GDM group were correlated with HOMA-IR, TG and blood glucose levels at 1 h and 2 h after glucose was administered (r = 0.49, 0.49, 0.52,0.52, respectively; p < 0.01). In conclusion, serum RBP4 levels are elevated in GDM cases than controls. In addition, RBP4 correlates with abnormalities of insulin resistance, glucose and lipid metabolism.
最近发现视黄醇结合蛋白 4（RBP4）在胰岛素抵抗中的作用。我们的研究在一项妊娠糖尿病（GDM）的病例对照研究中，调查了 RBP4 水平与血脂和糖代谢之间的相关性。2008 年 5 月至 2010 年 5 月期间，招募了 70 名孕妇（24-28 周妊娠），包括 35 名 GDM 妇女和 35 名健康对照者。在口服葡萄糖耐量试验（OGTT）前后采集血样，以检测血清 RBP4、胰岛素、糖化血红蛋白、甘油三酯（TG）和总胆固醇（TC）水平；计算胰岛素抵抗指数（HOMA-IR）。GDM 组的血清 RBP4 水平明显高于对照组（22.9±3.09µg/ml 与 17.9±3.91µg/ml；p<0.01）。GDM 组和对照组的胰岛素、TC 和 TG 水平均明显高于对照组（p<0.05）。GDM 组的血清 RBP4 水平与 HOMA-IR、服用葡萄糖后 1 小时和 2 小时的 TG 和血糖水平相关（r=0.49、0.49、0.52、0.52；均 p<0.01）。总之，GDM 病例的血清 RBP4 水平高于对照组。此外，RBP4 与胰岛素抵抗、葡萄糖和脂质代谢异常相关。
