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天然黄酮类化合物生物合成与生物活性的最新研究进展。

Recent insights into the biosynthesis and biological activities of natural xanthones.

机构信息

Pharmacognosy Division, Department of Medicinal Chemistry, Uppsala University, Biomedical Centre, Uppsala, Sweden.

出版信息

Curr Med Chem. 2010;17(9):854-901. doi: 10.2174/092986710790712147.

Abstract

This review focuses on recent advances in our understanding of the complex biosynthetic pathways and diverse biological activities of naturally occurring xanthones. The biosynthesis section covers studies published from 1989 to 2008 on xanthone production in plants and fungi, while the bioactivity review presents tabulated activities of more than 250 xanthones described in studies published from 2001 to 2008, together with structural information and indications of their wide-ranging potential uses as pharmacological tools. A large number of relevant papers have been published on these subjects (128 cited here), illustrating the diversity of the xanthones and their possible uses.

摘要

这篇综述重点介绍了近年来人们对天然黄烷酮复杂生物合成途径和多种生物活性的深入了解。生物合成部分涵盖了 1989 年至 2008 年期间发表的关于植物和真菌中黄烷酮产生的研究,而生物活性综述则列出了 2001 年至 2008 年期间发表的 250 多种黄烷酮的活性,同时还提供了结构信息,并指出了它们作为药理学工具的广泛应用潜力。关于这些主题已经发表了大量相关论文(此处引用了 128 篇),说明了黄烷酮的多样性及其可能的用途。

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