Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.
Interdisciplinary Center of Marine and Environmental Research (CIIMAR), University of Porto, Edificio do Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4050-208 Matosinhos, Portugal.
Molecules. 2019 Jan 16;24(2):314. doi: 10.3390/molecules24020314.
According to the World Health Organization, the exacerbated use of antibiotics worldwide is increasing multi-resistant infections, especially in the last decade. Xanthones are a class of compounds receiving great interest in drug discovery and development that can be found as natural products or obtained by synthesis. Many derivatives of xanthones are chiral and associated with relevant biological activities, including antimicrobial. The aim of this review is to compile information about chiral derivatives of xanthones from natural sources and their synthesized examples with antimicrobial activity.
根据世界卫生组织的说法，全球范围内抗生素的过度使用正在增加多重耐药感染，尤其是在过去十年中。黄烷酮类化合物是一类在药物发现和开发中受到广泛关注的化合物，可以作为天然产物存在，也可以通过合成获得。许多黄烷酮类化合物的衍生物是手性的，与相关的生物活性有关，包括抗菌活性。本综述的目的是汇编来自天然来源的黄烷酮类化合物的手性衍生物及其具有抗菌活性的合成实例的信息。
