人参多糖诱导小鼠腹腔巨噬细胞细胞毒活性。
Induction of tumoricidal activity in mouse peritoneal macrophages by ginseng polysaccharide.
机构信息
Department of Histology and Embryology, Chongqing Medical University, Yuzhong District, China.
出版信息
Int J Biol Macromol. 2010 May 1;46(4):389-95. doi: 10.1016/j.ijbiomac.2010.02.007. Epub 2010 Feb 13.
This study examined the effects of ginseng polysaccharide (GPS) on mouse peritoneal macrophage (PM)-mediated cytotoxicity towards K562, HL-60, or KG1alpha cells. GPS had no direct effect on killing of tumor cells. However, when mouse PMs were treated with GPS, cytotoxic activity against K562, HL-60, or KG1alpha cells was significantly induced. In addition, phagocytic activity was enhanced in GPS-treated mouse PMs compared to the control. The expressions of CD(68), ACP and alpha-ANE in mouse PMs were increased by the treatment with GPS. Moreover, the levels of cytokines, including tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), IL-6 were increased and the production of nitric oxide (NO) was enhanced. Taken together, these results suggest that GPS possess a potent antitumor activity by stimulating macrophage and a potentiality as an immunomodulator against diseases such as cancer.
本研究探讨了人参多糖（GPS）对小鼠腹腔巨噬细胞（PM）介导的杀伤 K562、HL-60 或 KG1alpha 细胞的影响。GPS 对肿瘤细胞的杀伤无直接作用。然而，当用 GPS 处理小鼠 PM 时，对 K562、HL-60 或 KG1alpha 细胞的细胞毒性活性显著诱导。此外，与对照组相比，在 GPS 处理的小鼠 PM 中吞噬活性增强。GPS 处理增加了小鼠 PM 中 CD（68）、ACP 和 alpha-ANE 的表达。此外，细胞因子水平，包括肿瘤坏死因子-α（TNF-α）、白细胞介素-1（IL-1）、IL-6 增加，一氧化氮（NO）的产生增强。综上所述，这些结果表明，GPS 通过刺激巨噬细胞具有强大的抗肿瘤活性，并具有作为癌症等疾病的免疫调节剂的潜力。
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