心境障碍的影像遗传学。
Imaging genetics of mood disorders.
机构信息
Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
出版信息
Neuroimage. 2010 Nov 15;53(3):810-21. doi: 10.1016/j.neuroimage.2010.02.019. Epub 2010 Feb 13.
Abstract
Mood disorders are highly heritable and have been linked to brain regions of emotion processing. Over the past few years, an enormous amount of imaging genetics studies has demonstrated the impact of risk genes on brain regions and systems of emotion processing in vivo in healthy subjects as well as in mood disorder patients. While sufficient evidence already exists for several monaminergic genes as well as for a few non-monoaminergic genes, such as brain-derived neurotrophic factor (BDNF) in healthy subjects, many others only have been investigated in single studies so far. Apart from these studies, the present review also covers imaging genetics studies applying more complex genetic disease models of mood disorders, such as epistasis and gene-environment interactions, and their impact on brain systems of emotion processing. This review attempts to provide a comprehensive overview of the rapidly growing field of imaging genetics studies in mood disorder research.
摘要
心境障碍具有高度遗传性，与情绪处理的大脑区域有关。在过去的几年中，大量的影像遗传学研究表明，风险基因会影响健康受试者和心境障碍患者的情绪处理的大脑区域和系统。虽然已经有足够的证据表明几种单胺能基因以及一些非单胺能基因（如脑源性神经营养因子（BDNF））在健康受试者中的作用，但到目前为止，许多其他基因仅在单项研究中得到了研究。除了这些研究，本综述还涵盖了应用更复杂的心境障碍遗传疾病模型（如上位性和基因-环境相互作用）的影像遗传学研究，以及它们对情绪处理的大脑系统的影响。本综述试图提供一个关于心境障碍研究中快速发展的影像遗传学研究领域的全面概述。
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