García-Montesinos-De la Peña M, Oteiza-López L, Aldunate-Calvo S, Gómez-Sánchez M J, Sáenz-Bañuelos J J, Tihista-Jiménez J A
Servicio de Medicina Intensiva, Hospital Virgen del Camino, Pamplona, Navarra, España.
Med Intensiva. 2010 Mar;34(2):150-3. doi: 10.1016/j.medin.2009.04.005. Epub 2009 Oct 2.
Herpes simplex virus bronchopneumonitis is a clinical entity described in critically ill patients and classically associated to immunosuppression. Recent reports have shown a higher frequency of virus detection from samples obtained by bronchoalveolar lavage of immunocompetent critically ill patients undergoing mechanical ventilation. This fact suggests its role as an independent pathogenic substrate. We report the case of a female patient who was admitted after an elective surgery of rectal tumor with suspected bronchoaspiration during anesthetic induction. The patient presented persistent fever despite broad spectrum antibiotic treatment. All cultures were negative for bacterial growth. The chest X-ray did not show opacifities. Prolonged mechanical ventilation with repeated failures to wean made it mandatory to perform percutaneous tracheostomy. A fibrobronchoscopy with bronchoalveolar lavage, performed previously, showed positive result for herpes simplex virus (PCR and specific nuclear inclusions in cells). Thus, treatment was initiated with acyclovir, with clinical improvement and weaning from mechanical ventilation.
单纯疱疹病毒性支气管肺炎是一种在重症患者中描述的临床实体,经典地与免疫抑制相关。最近的报告显示,在接受机械通气的免疫功能正常的重症患者的支气管肺泡灌洗样本中,病毒检测频率更高。这一事实表明其作为独立致病底物的作用。我们报告一例女性患者,该患者在择期直肠肿瘤手术后因麻醉诱导期间疑似支气管误吸而入院。尽管接受了广谱抗生素治疗,患者仍持续发热。所有培养物均未检测到细菌生长。胸部X光片未显示混浊。长时间机械通气且多次脱机失败,使得必须进行经皮气管切开术。先前进行的纤维支气管镜检查及支气管肺泡灌洗显示单纯疱疹病毒检测呈阳性(PCR及细胞中特异性核内包涵体)。因此,开始使用阿昔洛韦治疗,患者临床症状改善并成功脱机。