St. George Medical Center, Robert-Koch-Hospital, Nikolai-Rumjanzew 100 St., 04207 Leipzig, Germany.
Eur J Med Res. 2009 Dec 7;14 Suppl 4(Suppl 4):27-31. doi: 10.1186/2047-783x-14-s4-27.
In utero and/or childhood environmental tobacco smoke exposure is well known to adversely affect lung function and to depreciate child's health in many ways. Fewer studies have assessed the long-term effects on COPD development and disease severity in later adulthood.
COPD patients were interviewed using a structured questionnaire regarding their personal as well as the smoking habits of their parents. Data were compared with the disease history, e.g. COPD exacerbation rate, and their lung function data.
Between 2003 and 2004 COPD patients were recruited a) in a private practice specialized in pulmonary medicine (n = 133) and b) in a hospital (n = 158). 75% of their fathers and only 15.4 of all mothers smoked regularly. COPD patients from smoking mothers had lower FEV1 predicted than those raised in household without maternal smoking exposure: 39.4 +/- 9.5% vs. 51.9 +/- 6.0% (P = 0.037). Fathers had no effect on FEV1 regardless if they are smokers or non-smokers. Rate of severe exacerbations requiring hospitalization remained unaffected by parental second hand smoke exposure.
Maternal smoking negatively affects lung function of their offspring even in late adulthood when they develop COPD. It even aggravates the cumulative effect of active cigarette consumption. Clinical course of the COPD remained unaffected.
子宫内和/或儿童时期接触环境烟草烟雾已被证实会对肺功能产生不利影响，并在许多方面降低儿童的健康水平。然而，较少的研究评估了其对成年后慢性阻塞性肺疾病（COPD）发展和疾病严重程度的长期影响。
COPD 患者通过结构化问卷接受采访，内容涉及个人以及其父母的吸烟习惯。将数据与疾病史（例如 COPD 加重率）和肺功能数据进行比较。
在 2003 年至 2004 年间，我们在一家专门从事肺病学的私人诊所（n = 133）和一家医院（n = 158）招募了 COPD 患者。他们的父亲中有 75%，而所有母亲中只有 15.4%是经常吸烟者。与在没有母亲吸烟暴露的家庭中长大的 COPD 患者相比，来自吸烟母亲的患者的预计 FEV1 较低：39.4 +/- 9.5%对 51.9 +/- 6.0%（P = 0.037）。无论父亲是否吸烟，他们对 FEV1 都没有影响。父母接触二手烟不会影响严重恶化导致住院的频率。
即使在成年后发生 COPD 时，母亲吸烟也会对其子女的肺功能产生负面影响。它甚至会加重主动吸烟的累积影响。COPD 的临床病程不受影响。
