分娩时的可溶性I类组织相容性抗原（s-HLA）和β2-微球蛋白。
Soluble class I histocompatibility antigens (s-HLA) and beta 2-microglobulin at delivery.
作者信息
Ferreira A, García Rodríguez M C, Omeñaca F, Jiménez A, Villar L M, Gonzalez-Porqué P, Fontán G
机构信息
Immunology Unit, Hospital La Paz, Madrid Spain.
出版信息
Clin Exp Immunol. 1991 Apr;84(1):167-9.
In this work we have quantified soluble class I histocompatibility antigens (s-HLA) and beta 2-microglobulin (beta 2 m) in sera of HIV+ or HIV- mothers at delivery and in cord blood sera of their newborn children. The results obtained for beta 2 m show that cord blood sera of newborn children have higher concentrations than their mothers, implying that most of the beta 2 m in the newborn is self-produced as described previously. s-HLA serum concentrations in the newborn children are significantly lower than in their mothers or in age-matched controls. Moreover, HIV+ mothers have significantly higher serum concentrations than HIV- mothers or an age-matched control group. These results suggest that s-HLA does not cross the placental barrier.
在这项研究中，我们对分娩时HIV阳性或HIV阴性母亲的血清以及其新生儿脐带血血清中的可溶性I类组织相容性抗原（s-HLA）和β2-微球蛋白（β2m）进行了定量分析。β2m的检测结果表明，新生儿脐带血血清中的浓度高于其母亲，这意味着新生儿体内的大部分β2m如先前所述是自身产生的。新生儿血清中s-HLA的浓度显著低于其母亲或年龄匹配的对照组。此外，HIV阳性母亲的血清浓度显著高于HIV阴性母亲或年龄匹配的对照组。这些结果表明，s-HLA不会穿过胎盘屏障。
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