Seligmann M, Aucouturier P, Danon F, Preud'Homme J L
Laboratory of Immunochemistry and Immunopathology, (INSERM U 108), St Louis Hospital, Paris, France.
Clin Exp Immunol. 1991 Apr;84(1):23-7. doi: 10.1111/j.1365-2249.1991.tb08118.x.
Striking variations of serum immunoglobulin class and IgG subclass levels were observed in five patients with common variable immunodeficiency. They occurred mainly in untreated patients or, in those patients who received substitutive therapy, could not be merely due to replacement. They result in major changes in the immunoglobulin deficiency patterns, such as a shift from profound hypoimmunoglobulinaemia to IgA/IgG2/IgG4 deficiency or to isolated IgG2 deficiency. These findings have practical implications for the diagnosis and management of patients with primary humoral immunodeficiency.
在5例普通可变免疫缺陷患者中观察到血清免疫球蛋白类别和IgG亚类水平的显著变化。这些变化主要发生在未经治疗的患者中，或者在接受替代疗法的患者中，其变化不仅仅是由于替代治疗所致。它们导致免疫球蛋白缺乏模式的重大改变，例如从严重低免疫球蛋白血症转变为IgA/IgG2/IgG4缺乏或孤立的IgG2缺乏。这些发现对原发性体液免疫缺陷患者的诊断和管理具有实际意义。
