Hanson L A, Björkander J, Robbins J B, Schneerson R, Söderström R, Söderström T
Vox Sang. 1986;51 Suppl 2:50-6. doi: 10.1111/j.1423-0410.1986.tb02008.x.
IgG subclasses differ not only in their biochemical and biologic properties, but also in their occurrence as selective deficiencies, alone and in combination. The normal range of IgG subclass concentrations in children and adults is compared with deficiencies found in individuals with repeated respiratory tract infections. Concomitant IgA deficiency is often noted. It is suggested that decreased IgG2 and IgG3 levels in IgA-deficient individuals may increase the risk of recurrent respiratory infection and lung damage. Finally, the efficacy immunoglobulin. prophylaxis in reducing of infection is anecdotally related.
免疫球蛋白G亚类不仅在生化和生物学特性上有所不同，而且在单独或合并出现选择性缺陷的情况方面也存在差异。将儿童和成人免疫球蛋白G亚类浓度的正常范围与反复呼吸道感染个体中发现的缺陷情况进行了比较。常可注意到伴有免疫球蛋白A缺乏。有人提出，免疫球蛋白A缺乏个体中免疫球蛋白G2和免疫球蛋白G3水平降低可能会增加反复呼吸道感染和肺部损伤的风险。最后，免疫球蛋白预防在减少感染方面的疗效有一些传闻相关的报道。
