Söderström T, Söderström R, Hanson L A
Department of Clinical Immunoĺogy, University of Göteborg, Sweden.
Ann Clin Res. 1987;19(4):280-4.
Immunodeficiencies have been described ranging from stem cell dysfunction to low levels of isolated IgG subclasses. Subclass deficiencies seem in most cases to depend on regulatory defects rather than absence of genes encoding Ig heavy chains. It is, thus, not surprising that low levels of IgG subclasses can be seen in various immunodeficiency syndromes, where regulatory defects of the immune response may be present. Isolated IgG subclass deficiencies, however, are often found among patients with increased susceptibility to e.g. infections. The frequent B and/or T cell abnormalities observed in IgG subclass deficient individuals may explain the increased susceptibility to infections, suggesting that low subclass levels may function as an indicator of a clinically important immunodeficiency.
免疫缺陷的描述范围从干细胞功能障碍到孤立的IgG亚类水平低下。在大多数情况下，亚类缺陷似乎取决于调节缺陷，而非编码Ig重链的基因缺失。因此，在各种免疫缺陷综合征中可见IgG亚类水平低下就不足为奇了，因为这些综合征中可能存在免疫反应的调节缺陷。然而，孤立的IgG亚类缺陷常见于对例如感染易感性增加的患者中。在IgG亚类缺陷个体中观察到的频繁的B和/或T细胞异常可能解释了对感染易感性增加的原因，这表明亚类水平低下可能作为临床上重要免疫缺陷的一个指标。
