Yu Hui, Yu Fu-Dong, Zhang Guo-Qing, Shen Xiang, Chen Yun-Qin, Li Yuan-Yuan, Li Yi-Xue
Bioinformatics Center, Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, Shanghai Center for Bioinformation Technology, Shanghai 200235 and College of Life Science and Technology, Tongji University, Shanghai 200092, China.
Database (Oxford). 2009;2009:bap006. doi: 10.1093/database/bap006. Epub 2009 Jun 2.
DBH2H collects head-to-head (h2h) gene pairs identified from human, mouse, rat, chicken and fugu genomes, and distinguishes the ortholog mapping relationship among them. The gene pairs in DBH2H are annotated with sequential features including single nucleotide polymorphisms, CpG islands and transcription factor binding sites, as well as functional terms and genetic disorders. In addition, the expression correlation information based on 117 microarray datasets is included. By providing user-friendly access to these data, DBH2H represents a valuable resource for further analyses of this important gene arrangement in terms of transcriptional regulation mechanisms, evolutionary conservation, disease relevance, etc.Database URL:http://lifecenter.sgst.cn/h2h/
DBH2H收集了从人类、小鼠、大鼠、鸡和河豚基因组中鉴定出的一对一（h2h）基因对，并区分了它们之间的直系同源映射关系。DBH2H中的基因对用包括单核苷酸多态性、CpG岛和转录因子结合位点等序列特征以及功能术语和遗传疾病进行注释。此外，还包括基于117个微阵列数据集的表达相关信息。通过为用户提供对这些数据的便捷访问，DBH2H为从转录调控机制、进化保守性、疾病相关性等方面进一步分析这一重要基因排列提供了宝贵资源。数据库网址：http://lifecenter.sgst.cn/h2h/
