Loots Gabriela, Ovcharenko Ivan
CMLS 7000 East Avenue, Livermore, CA, 94550, USA.
Bioinformatics. 2007 Jan 1;23(1):122-4. doi: 10.1093/bioinformatics/btl546. Epub 2006 Nov 7.
Evolutionary conservation of DNA sequences provides a tool for the identification of functional elements in genomes. We have created a database of evolutionary conserved regions (ECRs) in vertebrate genomes, entitled ECRbase, which is constructed from a collection of whole-genome alignments produced by the ECR Browser. ECRbase features a database of syntenic blocks that recapitulate the evolution of rearrangements in vertebrates and a comprehensive collection of promoters in all vertebrate genomes generated using multiple sources of gene annotation. The database also contains a collection of annotated transcription factor binding sites (TFBSs) in evolutionary conserved and promoter elements. ECRbase currently includes human, rhesus macaque, dog, opossum, rat, mouse, chicken, frog, zebrafish and fugu genomes. It is freely accessible at http://ecrbase.dcode.org.
DNA序列的进化保守性为识别基因组中的功能元件提供了一种工具。我们创建了一个脊椎动物基因组进化保守区域（ECR）数据库，名为ECRbase，它是由ECR浏览器生成的全基因组比对集合构建而成。ECRbase的特色在于一个同线基因座数据库，该数据库概括了脊椎动物重排的进化过程，以及一个使用多种基因注释来源生成的所有脊椎动物基因组启动子的综合集合。该数据库还包含进化保守元件和启动子元件中注释的转录因子结合位点（TFBS）集合。ECRbase目前包括人类、恒河猴、狗、负鼠、大鼠、小鼠、鸡、青蛙、斑马鱼和河豚的基因组。可通过http://ecrbase.dcode.org免费访问。
