Keeping your senescent cells under control.
作者信息
Zender Lars, Rudolph K Lenhard
机构信息
Helmholtz Centre for Infection Research, Braunschweig, Germany.
出版信息
Aging (Albany NY). 2009 May 6;1(5):438-41. doi: 10.18632/aging.100046.
Abstract
摘要
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MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8.微小RNA miR-146a/b对衰老相关炎症介质白细胞介素-6和白细胞介素-8起负向调节作用。
Aging (Albany NY). 2009 Apr;1(4):402-11. doi: 10.18632/aging.100042.
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Senescence of activated stellate cells limits liver fibrosis.活化星状细胞的衰老限制肝纤维化。
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A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis.miR-146a基因中的功能性多态性与家族性乳腺癌/卵巢癌诊断年龄
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Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.由白细胞介素依赖性炎症网络介导的癌基因诱导的衰老
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Chemokine signaling via the CXCR2 receptor reinforces senescence.通过CXCR2受体的趋化因子信号传导会增强细胞衰老。
Cell. 2008 Jun 13;133(6):1006-18. doi: 10.1016/j.cell.2008.03.038.
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Cell. 2008 Feb 8;132(3):363-74. doi: 10.1016/j.cell.2007.12.032.
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Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.核酸外切酶1缺失会损害DNA损伤信号传导并延长端粒功能异常小鼠的寿命。
Cell. 2007 Sep 7;130(5):863-77. doi: 10.1016/j.cell.2007.08.029.
9
Cellular senescence: when bad things happen to good cells.细胞衰老：当好事发生在好细胞上时。 （注：原英文表述似乎不太符合正常逻辑，正常应该是不好的事情发生在细胞上才会导致衰老，这里按照字面意思翻译）
Nat Rev Mol Cell Biol. 2007 Sep;8(9):729-40. doi: 10.1038/nrm2233.
10
Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment.端粒功能障碍会引发环境改变，限制造血干细胞的功能和植入。
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