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Keeping your senescent cells under control.

作者信息

Zender Lars, Rudolph K Lenhard

机构信息

Helmholtz Centre for Infection Research, Braunschweig, Germany.

出版信息

Aging (Albany NY). 2009 May 6;1(5):438-41. doi: 10.18632/aging.100046.

DOI:10.18632/aging.100046
PMID:20157527
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2806024/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ed3/2806024/6e25408dd246/aging-01-438-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ed3/2806024/6e25408dd246/aging-01-438-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ed3/2806024/6e25408dd246/aging-01-438-g001.jpg

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MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8.微小RNA miR-146a/b对衰老相关炎症介质白细胞介素-6和白细胞介素-8起负向调节作用。
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ID1-induced p16/IL6 axis activation contributes to the resistant of hepatocellular carcinoma cells to sorafenib.
ID1 诱导的 p16/IL6 轴激活有助于肝癌细胞对索拉非尼的耐药性。
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Age-Associated Resident Memory CD8 T Cells in the Central Nervous System Are Primed To Potentiate Inflammation after Ischemic Brain Injury.中枢神经系统中与年龄相关的驻留记忆CD8 T细胞在缺血性脑损伤后被激活以增强炎症反应。
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[Immunogerontology - Research into aging].[免疫老年学——衰老研究]
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The canonical NF-κB pathway differentially protects normal and human tumor cells from ROS-induced DNA damage.经典的 NF-κB 通路可使正常细胞和人肿瘤细胞对 ROS 诱导的 DNA 损伤产生差异性保护。
Cell Signal. 2012 Nov;24(11):2007-23. doi: 10.1016/j.cellsig.2012.06.010. Epub 2012 Jun 29.
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What determines the switch between atrophic and neovascular forms of age related macular degeneration? - the role of BMP4 induced senescence.是什么决定了年龄相关性黄斑变性萎缩型和新生血管型之间的转变？——骨形态发生蛋白4诱导衰老的作用。
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Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.致癌性BRAF通过由分泌蛋白IGFBP7介导的途径诱导衰老和凋亡。
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Cellular senescence: when bad things happen to good cells.细胞衰老：当好事发生在好细胞上时。 （注：原英文表述似乎不太符合正常逻辑，正常应该是不好的事情发生在细胞上才会导致衰老，这里按照字面意思翻译）
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