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P66Shc向衰老发出信号。

P66Shc signals to age.

作者信息

Trinei Mirella, Berniakovich Ina, Beltrami Elena, Migliaccio Enrica, Fassina Ambrogio, Pelicci PierGiuseppe, Giorgio Marco

机构信息

Congenia Srl, 20139 Milan, Italy.

出版信息

Aging (Albany NY). 2009 Jun 5;1(6):503-10. doi: 10.18632/aging.100057.

DOI:10.18632/aging.100057
PMID:20157533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2806035/
Abstract

Oxygen metabolism is thought to impact on aging through the formation of reactive oxygen species (ROS) that are supposed to damage biological molecules. The study of p66(Shc), a crucial regulator of ROS level involved in aging dysfunction, suggests that the incidence of degenerative disease and longevity are determined by a specific signaling function of ROS other than their unspecific damaging property.

摘要

氧代谢被认为通过活性氧（ROS）的形成影响衰老，活性氧被认为会损害生物分子。对p66（Shc）的研究表明，退行性疾病的发生率和寿命是由活性氧的特定信号功能决定的，而不是由其非特异性损伤特性决定的。p66（Shc）是参与衰老功能障碍的活性氧水平的关键调节因子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b984/2806035/59a1d76ffdfc/aging-01-503-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b984/2806035/4509906d11e3/aging-01-503-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b984/2806035/96cd1f9a986c/aging-01-503-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b984/2806035/59a1d76ffdfc/aging-01-503-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b984/2806035/4509906d11e3/aging-01-503-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b984/2806035/96cd1f9a986c/aging-01-503-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b984/2806035/59a1d76ffdfc/aging-01-503-g003.jpg

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