Sirtuins at the breaking point: SIRT6 in DNA repair.
作者信息
Lombard David B
机构信息
Department of Pathology and Institute of Gerontology, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
Aging (Albany NY). 2009 Jan 20;1(1):12-6. doi: 10.18632/aging.100014.
Abstract
摘要
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Histone H3 K56 hyperacetylation perturbs replisomes and causes DNA damage.组蛋白H3第56位赖氨酸残基的高度乙酰化会扰乱复制体并导致DNA损伤。
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