Department of Medicinal Chemistry, Theodor Bilharz Research Institute (TBRI), Giza, Egypt.
Z Naturforsch C J Biosci. 2009 Nov-Dec;64(11-12):798-808. doi: 10.1515/znc-2009-11-1208.
A new triterpene saponin, named as 23-hydroxy-3alpha-[O-alpha-L-1C4-rhamnopyranosyl-(1"-->4')-O-alpha-L-4C1-arabinopyranosyl-oxy]olean-12-en-28-oic acid O-alpha-L-1C4-rhamnopyranosyl-(1""'-->4"")-O-beta-D-4C1-glucopyranosyl-(1""-->6"')-O-beta-D-4C1-glucopyranosyl ester (9), was isolated from the leaves of Bauhinia variegata Linn. In addition, six flavonoid compounds along with two cinnamic acid derivatives were isolated and identified based on their chromatographic properties, and chemical and spectral data (ESI-high resolution-MSn, 1H NMR, 13C NMR, 1H-1H COSY, HSQC, and HMBC). Compound 9 was found to be nontoxic (LD50) and to have significant anti-inflammatory and antinociceptive activities. It also showed a slight antischistosomal activity.
从白花油麻藤的叶子中分离得到一种新的三萜皂苷，命名为 23-羟基-3α-[O-α-L-1C4-鼠李吡喃糖基-(1"-->4')-O-α-L-4C1-阿拉伯吡喃糖基-氧基]齐墩-12-烯-28-酸 O-α-L-1C4-鼠李吡喃糖基-(1""'-->4"")-O-β-D-4C1-吡喃葡萄糖基-(1""-->6"')-O-β-D-4C1-吡喃葡萄糖基酯（9）。此外，还根据其色谱性质和化学光谱数据（ESI-高分辨-MS n、1H NMR、13C NMR、1H-1H COSY、HSQC 和 HMBC）从该植物中共分离鉴定了 6 种黄酮类化合物和 2 种肉桂酸衍生物。化合物 9 表现出无毒性（LD50），具有显著的抗炎和镇痛活性，同时还具有轻微的抗血吸虫活性。
