对南洋杉树脂的化学和生物学研究。
Chemical and biological investigation of Araucaria heterophylla Salisb. resin.
机构信息
Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia.
出版信息
Z Naturforsch C J Biosci. 2009 Nov-Dec;64(11-12):819-23. doi: 10.1515/znc-2009-11-1211.
Three labdane diterpenes, namely lambda-8(17),14-diene, 13-epicupressic acid, and 13-Oacetyl-13-epicupressic acid, were isolated from the resin collected from stem exudates of Araucaria heterophylla Salisb. (Araucariaceae). The isolated compounds were identified using different spectroscopic methods (1H NMR, 13C NMR, HMQC, HMBC and COSY). The resin extract showed antiulcerogenic activity against ethanol-induced stomach ulcers in Sprauge Dawely rats using ranitidine as standard. In addition, the resin and the isolated compounds showed variable cytotoxic activities against breast (MCF7) and colon (HCT116) cancer cell lines.
从南洋杉（南洋杉科）茎渗出物收集的树脂中分离到三种拉伯烷二萜：λ-8(17),14-二烯、13-表扁柏酸和 13-O-乙酰基-13-表扁柏酸。使用不同的光谱方法（1H NMR、13C NMR、HMQC、HMBC 和 COSY）鉴定了分离出的化合物。该树脂提取物在使用雷尼替丁作为标准的情况下，对 Sprauge Dawely 大鼠的乙醇诱导的胃溃疡具有抗溃疡生成活性。此外，树脂和分离出的化合物对乳腺癌（MCF7）和结肠癌（HCT116）癌细胞系表现出不同的细胞毒性活性。
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