Department of Biomedical Sciences, Faculty of Medicine and Biomedical Sciences, MAHSA University, Jenjarom, Selangor 42610, Malaysia.
Department of Biotechnology, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology, Sholinganallur, Chennai, Tamil Nadu 600119, India.
Int J Nanomedicine. 2020 Sep 25;15:7097-7115. doi: 10.2147/IJN.S259653. eCollection 2020.
Plant gums consist of polysaccharides which can be used in the preparation of nanocarriers and provide a wide application in pharmaceutical applications including as drug delivery agents and the matrices for drug release. The objectives of the study were to collect plant gums from L and L and to extract and characterize their polysaccharides. Then to utilize these plant gum-derived polysaccharides for the formulation of nanocarriers to use for drug loading and to examine their purpose in drug delivery in vitro.
Plant gum was collected, polysaccharide was extracted, purified, characterized using UV-Vis, FTIR, TGA and GCMS and subjected to various bioactive studies. The purified polysaccharide was used for making curcumin-loaded nanocarriers using STMP (sodium trimetaphosphate). Bioactivities were performed on the crude, purified and drug-loaded nanocarriers. These polysaccharide-based nanocarriers were characterized using UV-Vis spectrophotometer, FTIR, SEM, and AFM. Drug release kinetics were performed for the drug-loaded nanocarriers.
The presence of glucose, xylose and sucrose was studied from the UV-Vis and GCMS analysis. Purified polysaccharides of both the plants showed antioxidant activity and also antibacterial activity against sp. Purified polysaccharides were used for nanocarrier synthesis, where the size and shape of the nanocarriers were studied using SEM analysis and AFM analysis. The size of the drug-loaded nanocarriers was found to be around 200 nm. The curcumin-loaded nanocarriers were releasing curcumin slow and steady.
The extracted pure polysaccharide of and acted as good antioxidants and showed antibacterial activity against sp. These polysaccharides were fabricated into curcumin-loaded nanocarriers whose size was below 200 nm. Both the drug-loaded nanocarriers synthesized using and showed antibacterial activity with a steady drug release profile. Hence, these natural exudates can serve as biodegradable nanocarriers in drug delivery.
植物胶由多糖组成，可用于制备纳米载体，并在制药应用中提供广泛的应用，包括作为药物递送剂和药物释放基质。本研究的目的是从 L 和 L 中收集植物胶，并提取和表征其多糖。然后利用这些植物胶衍生的多糖来制备纳米载体用于药物负载，并在体外研究其在药物传递中的用途。
收集植物胶，提取、纯化多糖，使用 UV-Vis、FTIR、TGA 和 GCMS 进行表征，并进行各种生物活性研究。将纯化的多糖用于使用 STMP（三聚磷酸钠）制备姜黄素负载的纳米载体。对粗提物、纯化物和载药纳米载体进行生物活性研究。使用 UV-Vis 分光光度计、FTIR、SEM 和 AFM 对基于多糖的纳米载体进行表征。对载药纳米载体进行药物释放动力学研究。
通过 UV-Vis 和 GCMS 分析研究了葡萄糖、木糖和蔗糖的存在。两种植物的纯化多糖均表现出抗氧化活性，并且对 sp 具有抗菌活性。纯化多糖用于纳米载体合成，通过 SEM 分析和 AFM 分析研究了纳米载体的大小和形状。载药纳米载体的大小约为 200nm。姜黄素载药纳米载体缓慢而稳定地释放姜黄素。
从 L 和 L 中提取的纯多糖作为良好的抗氧化剂，对 sp 表现出抗菌活性。这些多糖被制成姜黄素载药纳米载体，其尺寸小于 200nm。使用 和 合成的载药纳米载体均表现出抗菌活性，并具有稳定的药物释放曲线。因此，这些天然渗出物可以作为药物传递中的可生物降解纳米载体。
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