Robbers Sylvana C C, Bartels Meike, van Oort Floor V A, van Beijsterveldt C E M Toos, van der Ende Jan, Verhulst Frank C, Boomsma Dorret I, Huizink Anja C
Department of Child and Adolescent Psychiatry, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
Twin Res Hum Genet. 2010 Feb;13(1):79-87. doi: 10.1375/twin.13.1.79.
Research on twin-singleton differences in externalizing and internalizing problems in childhood is largely cross-sectional and yields contrasting results. The goal of this study was to compare developmental trajectories of externalizing and internalizing problems in 6- to 12-year-old twins and singletons. Child Behavior Checklist (CBCL) maternal reports of externalizing and internalizing problems were obtained for a sample of 9651 twins from the Netherlands Twin Register and for a representative general population sample of 1351 singletons. Latent growth modeling was applied to estimate growth curves for twins and singletons. Twin-singleton differences in the intercepts and slopes of the growth curves were examined. The developmental trajectories of externalizing problems showed a linear decrease over time, and were not significantly different for twins and singletons. Internalizing problems seem to develop similarly for twins and singletons up to age 9. After this age twins' internalizing symptoms start to decrease in comparison to those of singletons, resulting in less internalizing problems than singletons by the age of 12 years. Our findings confirm the generalizability of twin studies to singleton populations with regard to externalizing problems in middle and late childhood. The generalizability of studies on internalizing problems in early adolescence in twin samples should be addressed with care. Twinship may be a protective factor in the development of internalizing problems during early adolescence.
关于儿童期外化问题和内化问题中双胞胎与单胞胎差异的研究大多是横断面研究,且结果相互矛盾。本研究的目的是比较6至12岁双胞胎和单胞胎外化问题和内化问题的发展轨迹。从荷兰双胞胎登记处获取了9651对双胞胎样本以及1351名单胞胎的代表性普通人群样本的儿童行为检查表(CBCL)中母亲报告的外化问题和内化问题情况。应用潜在增长模型来估计双胞胎和单胞胎的增长曲线。检验了增长曲线截距和斜率方面的双胞胎与单胞胎差异。外化问题的发展轨迹显示随时间呈线性下降,双胞胎和单胞胎之间无显著差异。内化问题在9岁之前,双胞胎和单胞胎的发展情况似乎相似。9岁之后,与单胞胎相比,双胞胎的内化症状开始减少,到12岁时内化问题比单胞胎少。我们的研究结果证实了双胞胎研究在儿童中后期外化问题方面对单胞胎人群的可推广性。对于双胞胎样本中青少年早期内化问题研究的可推广性应谨慎对待。双胞胎关系可能是青少年早期内化问题发展过程中的一个保护因素。