Mitchell J D, East B W, Harris I A, Pentland B
Department of Neurology, Royal Preston Hospital, UK.
Eur Neurol. 1991;31(1):7-11. doi: 10.1159/000116626.
Trace element levels were measured by neutron activation analysis in spinal cord, liver and bone of 7 control patients dying of non-neurological disease and 15 patients dying of motor neurone disease (MND). The concentration of selenium was significantly elevated in the cervical cord, liver and bone in the MND group. Although spinal cord manganese levels were increased at both the cervical and thoracic levels, the hepatic concentration was reduced in the MND patients. These findings are discussed in relation to current understanding of the pathogenesis of MND.
通过中子活化分析测定了7例死于非神经疾病的对照患者以及15例死于运动神经元病（MND）患者脊髓、肝脏和骨骼中的微量元素水平。MND组颈髓、肝脏和骨骼中的硒浓度显著升高。虽然MND患者颈段和胸段脊髓的锰水平均升高，但肝脏中的锰浓度降低。结合目前对MND发病机制的认识对这些发现进行了讨论。
