Mitchell J D, Harris I A, East B W, Pentland B
Br Med J (Clin Res Ed). 1984 Jun 16;288(6433):1791-2. doi: 10.1136/bmj.288.6433.1791.
Concentrations of sodium, chlorine, potassium, chromium, iron, cobalt, zinc, rubidium, silver, caesium, and selenium in cerebrospinal fluid from 14 control subjects and 20 patients with motor neurone disease were measured by in vitro neutron activation analysis. No statistically significant correlation was found between the concentrations of any two elements other than sodium and chlorine in either the patient or control group (r = 0.9905; p less than 0.001). The mean cobalt concentration was significantly lower in the patients (p = 0.0015). No other statistically significant difference was shown. The relevance of this finding was examined in relation to current concepts of the pathogenesis of motor neurone disease and the role of cobalt in cellular metabolism.
采用体外中子活化分析法，对14名对照者和20例运动神经元病患者脑脊液中的钠、氯、钾、铬、铁、钴、锌、铷、银、铯和硒浓度进行了测定。在患者组或对照组中，除钠和氯外，任何两种元素的浓度之间均未发现有统计学意义的相关性（r = 0.9905；p < 0.001）。患者组的平均钴浓度显著较低（p = 0.0015）。未显示出其他有统计学意义的差异。结合运动神经元病发病机制的当前概念以及钴在细胞代谢中的作用，对这一发现的相关性进行了研究。
