California Institute of Technology, Pasadena, CA 91125 , USA.
Biotechniques. 2005 Dec;39(6 Suppl):S6-13. doi: 10.2144/000112090.
This paper reviews the current state of research in spectral domain optical coherence tomography (SDOCT). SDOCT is an interferometric technique that provides depth-resolved tissue structure information encoded in the magnitude and delay of the back-scattered light by spectral analysis of the interference fringe pattern. There are two approaches to SDOCT--one that uses a broadband source and a spectrometer to measure the interference pattern as a function of wavelength and the other that utilizes a narrowband tunable laser that is swept linearly in k approximately 1/lambda space during spectral fringe data acquisition. Unlike time domain (TD) OCT, the reference arm is stationary in both SDOCT methods, which allows for ultra high-speed OCT imaging. Owing to its high speed and superior sensitivity, SDOCT has become indispensable in biomedical imaging applications. After a brief introduction and a discussion on sensitivity advantage, methods of implementation of the two SDOCT schemes will be presented. The two peer approaches are compared in speed, scan depth range, complexity, spectral regions of operation, and methods of detection. The review also discusses OCT enhancements and functional methods based on SDOCT format and concludes with possible directions that this research may take in the near future.
本文综述了光谱域光学相干断层扫描（SDOCT）的研究现状。SDOCT 是一种干涉技术，通过对干涉条纹图案的光谱分析，提供编码在背向散射光的幅度和延迟中的深度分辨组织结构信息。SDOCT 有两种方法——一种是使用宽带光源和光谱仪来测量随波长变化的干涉图案，另一种是利用窄带可调谐激光，在光谱条纹数据采集期间在线性扫过 k 约为 1/λ的空间。与时域（TD）OCT 不同，两种 SDOCT 方法中的参考臂都是静止的，这允许进行超高速度 OCT 成像。由于其高速和优异的灵敏度，SDOCT 已成为生物医学成像应用中不可或缺的工具。在简要介绍和讨论灵敏度优势之后，将介绍两种 SDOCT 方案的实现方法。在速度、扫描深度范围、复杂性、工作光谱区域以及检测方法方面对这两种对等方法进行了比较。综述还讨论了基于 SDOCT 格式的 OCT 增强和功能方法，并对该研究在不久的将来可能采取的方向进行了总结。
