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用于全范围多普勒光谱域光学相干断层扫描的抛物线型B型扫描技术

Parabolic BM-scan technique for full range Doppler spectral domain optical coherence tomography.

作者信息

Jaillon Franck, Makita Shuichi, Yabusaki Masaki, Yasuno Yoshiaki

机构信息

Computational Optics Group in the University of Tsukuba, Tsukuba, Ibaraki, Japan.

出版信息

Opt Express. 2010 Jan 18;18(2):1358-72. doi: 10.1364/OE.18.001358.

Abstract

A full range spectral domain optical coherence tomography (SD-OCT) technique that relies on the linear phase modulation of one of the interferometer arms has been widely utilized. Although this method is useful, the mirror image elimination is not perfect for samples in which regions with high axial motion exist. In this paper, we introduce a new modulation pattern to overcome this mirror image elimination failure. This new modulation is a parabolic phase modulation in the transverse scanning direction, and is applied to the SD-OCT reference beam by an electro-optic modulator. Flow phantom and in vivo experiments demonstrate that for moving structures with large velocities, this parabolic phase modulation technique presents better mirror image elimination than a standard linear phase modulation method. A direct consequence of this enhanced mirror image removal is an improved velocity range obtained with phase-resolved Doppler imaging. Consequently, applying the proposed technique in retinal blood flow measurements may be useful for ophthalmologic diagnosis.

摘要

一种依赖干涉仪臂之一的线性相位调制的全范围光谱域光学相干断层扫描(SD - OCT)技术已被广泛应用。尽管这种方法很有用,但对于存在高轴向运动区域的样本,镜像消除并不完美。在本文中,我们引入一种新的调制模式来克服这种镜像消除失败的问题。这种新的调制是横向扫描方向上的抛物线相位调制,并通过电光调制器应用于SD - OCT参考光束。流动模型和体内实验表明,对于具有大速度的移动结构,这种抛物线相位调制技术比标准线性相位调制方法具有更好的镜像消除效果。这种增强的镜像去除的直接结果是通过相位分辨多普勒成像获得了改进的速度范围。因此,将所提出的技术应用于视网膜血流测量可能对眼科诊断有用。

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