Entest BioMedical, San Diego, CA, USA.
J Transl Med. 2010 Feb 16;8:16. doi: 10.1186/1479-5876-8-16.
The medical use of low level laser (LLL) irradiation has been occurring for decades, primarily in the area of tissue healing and inflammatory conditions. Despite little mechanistic knowledge, the concept of a non-invasive, non-thermal intervention that has the potential to modulate regenerative processes is worthy of attention when searching for novel methods of augmenting stem cell-based therapies. Here we discuss the use of LLL irradiation as a "photoceutical" for enhancing production of stem cell growth/chemoattractant factors, stimulation of angiogenesis, and directly augmenting proliferation of stem cells. The combination of LLL together with allogeneic and autologous stem cells, as well as post-mobilization directing of stem cells will be discussed.
低水平激光(LLL)照射在医学上的应用已经有几十年的历史了,主要集中在组织愈合和炎症等领域。尽管对其作用机制的了解甚少,但这种非侵入性、非热干预的概念,有可能调节再生过程,因此在寻找增强基于干细胞的治疗方法时值得关注。在这里,我们讨论了将低水平激光照射作为一种“光药”来增强干细胞生长/趋化因子的产生、刺激血管生成,并直接增强干细胞的增殖。我们还将讨论低水平激光照射与同种异体和自体干细胞的联合应用,以及动员后对干细胞的定向作用。