Department of Obstetrics and Gynecology, Sao Paulo Federal University Family Planning Clinic/UNIFESP, São Paulo, Brazil.
Contraception. 2010 Mar;81(3):223-5. doi: 10.1016/j.contraception.2009.10.007. Epub 2009 Nov 14.
Oral contraceptives used for extended periods of time have been extensively studied because of their potential benefits; however, there have been few publications on extended regimens of vaginal contraceptive rings. The aim of this study was to evaluate the clinical symptoms, body weight and blood pressure changes in women using the vaginal ring continuously over a 1-year period.
This prospective cohort evaluated clinical aspects (dysmenorrhea, headache, breast tenderness, leg pain and irritability), body weight and blood pressure changes in 75 women (18-37 years of age) using a vaginal ring releasing 120 mcg of etonogestrel and 15 mcg of ethinyl estradiol daily, over a continuous period of 84 days, followed by a 7-day ring-free interval, during 1 year. The chi-square, Wilcoxon and paired t tests were used to analyze differences in the outcomes of interest.
Compared to pre-enrollment status, at the end of the study period, the patients reported significantly less dysmenorrhea and irritability, a nonsignificant decrease in breast tenderness, leg pain and headaches. Blood pressure measurements remained unchanged. Although weight and body mass index increased significantly among users, they remained within the expected biological variation range.
The vaginal ring used on an extended regimen is a well-tolerated contraceptive method and also offers noncontraceptive benefits.
长期使用口服避孕药因其潜在益处而得到广泛研究；然而，关于阴道避孕环的延长使用方案的出版物却很少。本研究旨在评估连续使用阴道环 1 年期间女性的临床症状、体重和血压变化。
本前瞻性队列研究评估了 75 名（18-37 岁）使用阴道环（每日释放 120 mcg 依托孕烯和 15 mcg 炔雌醇）的女性的临床方面（痛经、头痛、乳房触痛、腿痛和易怒）、体重和血压变化，连续使用 84 天，随后是 7 天无环间隔，持续 1 年。使用卡方检验、Wilcoxon 检验和配对 t 检验分析感兴趣结局的差异。
与入组前相比，在研究期末，患者报告的痛经和易怒明显减少，乳房触痛、腿痛和头痛无明显减少。血压测量保持不变。尽管使用者的体重和体重指数显著增加，但仍在预期的生物学变异范围内。
延长使用阴道环是一种耐受良好的避孕方法，并且还具有非避孕益处。
