Department of Paediatrics and Child Health, School of Medicine, Makerere University, Kampala, Uganda.
Ann Epidemiol. 2010 Mar;20(3):210-6. doi: 10.1016/j.annepidem.2009.11.001.
We determined whether human immunodeficiency virus (HIV) infection affects body cell mass and fat mass wasting among adults with pulmonary tuberculosis (PTB).
We screened 967 Ugandan adults for PTB and HIV infection in a cross-sectional study. We compared anthropometric and bioelectric impedance analysis (BIA) body composition parameters among HIV-seropositive and HIV-seronegative men and women with or without PTB by using a non-parametric test.
We found that poor nutritional status associated with TB differed among men and women. Anthropometric and BIA body composition did not differ between HIV-seropositive and HIV-seronegative patients regardless of gender. Average weight group difference in men consisted of body cell mass and fat mass in equal proportions of 43%. In women, average weight group difference consisted predominantly of fat mass of 73% and body cell mass of 13%. Compared to individuals without TB, patients with TB had lower body mass index, weight, body cell mass, and fat mass regardless of gender and HIV status.
Gender, but not HIV status, was associated with body composition changes in TB. TB appears to be the dominant factor driving the wasting process among co-infected patients.
我们旨在确定人类免疫缺陷病毒（HIV）感染是否会影响肺结核（PTB）成人的身体细胞质量和脂肪质量损失。
我们在一项横断面研究中筛选了 967 名乌干达成年人的 PTB 和 HIV 感染情况。我们通过非参数检验比较了 HIV 血清阳性和 HIV 血清阴性的男性和女性中有无 PTB 的人群的人体测量学和生物电阻抗分析（BIA）身体成分参数。
我们发现，与 TB 相关的营养不良状况在男性和女性中存在差异。无论性别如何，HIV 血清阳性和 HIV 血清阴性患者的人体测量学和 BIA 身体成分均无差异。男性平均体重组差异包括身体细胞质量和脂肪质量的比例相等，为 43%。在女性中，平均体重组差异主要是脂肪质量占 73%，身体细胞质量占 13%。与无 TB 的个体相比，无论 HIV 状况如何，TB 患者的体重指数、体重、身体细胞质量和脂肪质量均较低。
性别而不是 HIV 状态与 TB 患者的身体成分变化有关。TB 似乎是合并感染患者消耗过程的主要因素。
