胰腺癌的内镜超声分期及新型治疗方法

Endoscopic ultrasound staging and novel therapeutics for pancreatic cancer.

作者信息

Owens David J, Savides Thomas J

机构信息

Division of Gastroenterology, University of California, 9500 Gilman Drive, La Jolla, CA 92093-0063, USA.

出版信息

Surg Oncol Clin N Am. 2010 Apr;19(2):255-66. doi: 10.1016/j.soc.2009.11.009.

DOI:10.1016/j.soc.2009.11.009

PMID:20159514

Abstract

Pancreatic cancer remains a challenging disease, being the fourth leading cause of death in both men and women in the United States. Patients with pancreatic cancer present with symptoms including jaundice, pruritus, and weight loss, which often herald advanced disease with little chance for curative resection. Multiple imaging modalities are used to diagnose and stage pancreatic cancer. This article discusses the utility of endoscopic ultrasound (EUS) for diagnosis and staging, and introduces novel EUS-guided therapeutic options for the treatment of pancreatic cancers. EUS-guided fine-needle injection of chemotherapy agents is a promising development in pancreatic tumor treatment.

摘要

胰腺癌仍然是一种具有挑战性的疾病，在美国是男性和女性的第四大死因。胰腺癌患者会出现黄疸、瘙痒和体重减轻等症状，这些症状往往预示着疾病已进展到晚期，治愈性切除的机会很小。多种成像方式用于诊断胰腺癌并确定其分期。本文讨论了内镜超声（EUS）在诊断和分期方面的应用，并介绍了用于治疗胰腺癌的新型EUS引导下的治疗选择。EUS引导下细针注射化疗药物是胰腺癌治疗中一个有前景的进展。