胰腺癌研究的新前沿

New frontiers in pancreatic cancer research.

作者信息

Khan Gazala N, di Magliano Marina Pasca, Simeone Diane M

机构信息

Department of Internal Medicine, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA.

出版信息

Surg Oncol Clin N Am. 2010 Apr;19(2):431-51. doi: 10.1016/j.soc.2009.11.010.

DOI:10.1016/j.soc.2009.11.010

PMID:20159524

Abstract

Pancreatic adenocarcinoma (PDA) is a highly lethal and aggressive malignancy with high mortality rates. It is critical to evaluate novel therapeutic strategies and targets for the treatment of this disease. In this article, the authors describe the important areas of focus in pancreatic cancer research, recent advances in these areas, and novel approaches that have the potential to bring about positive patient outcomes in this lethal disease. This article also focuses on recent developments in identifying new, more sensitive, and more specific blood biomarkers with potential use in the early detection of PDA.

摘要

胰腺腺癌（PDA）是一种具有高死亡率的高度致命性和侵袭性恶性肿瘤。评估针对该疾病的新型治疗策略和靶点至关重要。在本文中，作者描述了胰腺癌研究的重要重点领域、这些领域的最新进展，以及有可能在这种致命疾病中为患者带来积极治疗效果的新方法。本文还重点介绍了在识别具有早期检测PDA潜在用途的新型、更敏感和更特异的血液生物标志物方面的最新进展。