Pour P M
Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha 68105.
Am J Surg Pathol. 1989;13 Suppl 1:96-103.
Pancreatic cancer induced in hamsters offers a unique model for studying important aspects of the disease. Studies of the mechanisms of carcinogenesis show that carcinogens require specific molecular structures for pancreatotrophic action. The neoplastic effects of these carcinogens is humoral, rather than operating through the bile reflux mechanism. Moreover, islet cells seem to play a direct or indirect role in cancer induction. Experiments concerning tumor histogenesis show that ductal/ductular cells are the progenitor cells of induced tumors. The proliferation of endocrine cells during the early stages of cancer development seems to be associated with a functional abnormality of the endocrine pancreas. Hormone secretions are altered in the serum and pancreatic juice. Furthermore, production of blood group-related antigens, particularly of A antigen, is characteristic for early cancer development and represents a tumor-specific antigen. Encouraging results have been obtained for the use of an anti-A antibody in early detection and therapy of this experimentally induced pancreatic cancer.
仓鼠诱发的胰腺癌为研究该疾病的重要方面提供了一个独特的模型。致癌机制研究表明，致癌物需要特定的分子结构才能产生促胰腺作用。这些致癌物的肿瘤形成作用是通过体液途径，而非通过胆汁反流机制起作用。此外，胰岛细胞似乎在癌症诱发中起直接或间接作用。有关肿瘤组织发生的实验表明，导管/小导管细胞是诱发肿瘤的祖细胞。癌症发展早期内分泌细胞的增殖似乎与内分泌胰腺的功能异常有关。血清和胰液中的激素分泌发生改变。此外，血型相关抗原，尤其是A抗原的产生是癌症早期发展的特征，代表一种肿瘤特异性抗原。在这种实验性诱发的胰腺癌的早期检测和治疗中使用抗A抗体已取得了令人鼓舞的结果。
