University of Pennsylvania, 1016B Abramson Research Center, 3615 Civic Center Blvd., Philadelphia, PA 19104-6160, USA.
Am J Respir Cell Mol Biol. 2010 Apr;42(4):385-93. doi: 10.1165/rcmb.2010-0026RT. Epub 2010 Feb 16.
Both malignant pleural mesothelioma and advanced stage lung cancer are associated with a poor prognosis. Unfortunately, current treatment regimens have had only a modest effect on their progressive course. Gene therapy for thoracic malignancies represents a novel therapeutic approach and has been evaluated in a number of clinical trials over the last two decades. Using viral vectors or anti-sense RNA, strategies have included induction of apoptosis, tumor suppressor gene replacement, suicide gene expression, cytokine-based therapy, various vaccination approaches, and adoptive transfer of modified immune cells. This review will consider the clinical results, limitations, and future directions of gene therapy trials for thoracic malignancies.
恶性胸膜间皮瘤和晚期肺癌预后均较差。不幸的是，目前的治疗方案对其进展过程的影响有限。胸内恶性肿瘤的基因治疗代表了一种新的治疗方法，在过去的二十年中，已在许多临床试验中进行了评估。使用病毒载体或反义 RNA，策略包括诱导细胞凋亡、肿瘤抑制基因替代、自杀基因表达、细胞因子治疗、各种疫苗接种方法以及修饰免疫细胞的过继转移。这篇综述将考虑胸内恶性肿瘤基因治疗试验的临床结果、局限性和未来方向。
