Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.
Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):884-7. doi: 10.1158/1055-9965.EPI-09-1295. Epub 2010 Feb 16.
Dietary choline and betaine have been hypothesized to decrease the risk of cancer because of their role as methyl donors in the one-carbon metabolism. However, it remains unknown whether dietary intake of choline and betaine is associated with colorectal cancer risk. We prospectively examined the associations between dietary choline and betaine intake and risk of colorectal cancer in men in the Health Professionals Follow-up Study. We followed 47,302 men and identified a total of 987 incident colorectal cancer cases from 1986 to 2004. We assessed dietary and supplemental choline and betaine intake every 4 years using a validated semiquantitative food frequency questionnaire. The Cox proportional hazards model was used to estimate multivariate relative risks and 95% confidence intervals. All statistical tests were two-sided. We did not find any statistically significant associations between choline intake or betaine intake and risk of colorectal cancer. Comparing the top quintile with bottom quintile, multivariate relative risks (95% confidence interval) were 0.97 (0.79-1.20; P(trend) = 0.87) for choline intake and 0.94 (0.77-1.16; P(trend) = 0.79) for betaine intake. Similarly, we observed no associations between colorectal cancer risk and choline from free choline, glycerophosphocholine, phosphocholine, phosphatidylcholine, or sphingomyelin. Our data do not support the hypothesis that choline and betaine intake is inversely associated with colorectal cancer risk.
饮食中的胆碱和甜菜碱由于其在一碳代谢中作为甲基供体的作用，被认为可以降低癌症的风险。然而，饮食中胆碱和甜菜碱的摄入量是否与结直肠癌风险有关仍不清楚。我们前瞻性地研究了男性健康专业人员随访研究中饮食中胆碱和甜菜碱的摄入量与结直肠癌风险之间的关系。我们随访了 47302 名男性，从 1986 年到 2004 年共发现了 987 例结直肠癌新发病例。我们每 4 年使用经过验证的半定量食物频率问卷评估饮食和补充胆碱和甜菜碱的摄入量。Cox 比例风险模型用于估计多变量相对风险和 95%置信区间。所有统计检验均为双侧。我们没有发现胆碱摄入或甜菜碱摄入与结直肠癌风险之间存在任何统计学上显著的关联。与最低五分位数相比，最高五分位数的多变量相对风险（95%置信区间）分别为 0.97（0.79-1.20；P（趋势）=0.87）的胆碱摄入和 0.94（0.77-1.16；P（趋势）=0.79）的甜菜碱摄入。同样，我们没有观察到结直肠癌风险与游离胆碱、甘油磷酸胆碱、磷酸胆碱、磷脂酰胆碱或鞘磷脂中的胆碱之间存在任何关联。我们的数据不支持胆碱和甜菜碱摄入与结直肠癌风险呈负相关的假设。
