Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Eur J Clin Nutr. 2010 Jan;64(1):111-4. doi: 10.1038/ejcn.2009.109. Epub 2009 Aug 26.
Evidence suggests that nutrients involved in one-carbon metabolism are implicated in ovarian cancer etiology. No studies have evaluated the role of choline, and that of its metabolite, betaine. We prospectively examined the relationship between the intake of these nutrients and ovarian cancer risk among 159 957 participants from the Nurses' Health Study (NHS) and NHSII. The average nutrient intake was assessed every 2-4 years beginning in 1984 (for NHS) and in 1991 (for NHSII). With up to 22 years of follow-up per cohort, 526 incident cases of ovarian cancer were diagnosed. There were no associations between total choline, betaine, as well as choline plus betaine intake and ovarian cancer risk (for example, relative risk, top vs bottom quintile of choline=0.98; 95% confidence interval: 0.73-1.31; P(trend)=0.81). Results did not vary by alcohol consumption, folate intake or after the exclusion of cases diagnosed during the 4-year period after dietary assessment. These data provide little evidence for a role of these nutrients in ovarian cancer etiology.
有证据表明，参与一碳代谢的营养素与卵巢癌的病因有关。目前还没有研究评估胆碱及其代谢物甜菜碱的作用。我们前瞻性地研究了 159957 名护士健康研究（NHS）和 NHSII 参与者的这些营养素摄入与卵巢癌风险之间的关系。从 1984 年（NHS）和 1991 年（NHSII）开始，每 2-4 年评估一次平均营养素摄入量。每个队列的随访时间长达 22 年，共诊断出 526 例卵巢癌病例。总胆碱、甜菜碱以及胆碱加甜菜碱的摄入与卵巢癌风险之间没有关联（例如，胆碱最高五分位与最低五分位的相对风险=0.98；95%置信区间：0.73-1.31；P（趋势）=0.81）。结果不因酒精摄入量、叶酸摄入量而变化，也不因排除膳食评估后 4 年内诊断出的病例而变化。这些数据几乎没有提供这些营养素在卵巢癌病因学中的作用的证据。
