Department of Neurology, Utano National Hospital, Kyoto, Japan.
Eur Neurol. 2010;63(3):159-63. doi: 10.1159/000283929. Epub 2010 Feb 16.
In order to clarify the immunological characteristics of multiple sclerosis (MS) and neuromyelitis optica (NMO), we analyzed CD3, CD4, CD8, CD20, CD4(+)CD25(+), CD4(+)CD29(+), and CD8(+)CD11a(high) cells in peripheral blood from patients with MS (16 stable, 6 active) and NMO (15 stable, 7 active), as well as 9 with NMO spectrum, 6 with clinically isolated syndrome (CIS), and 13 with other neurological diseases using flow cytometry. Significant decreases in the numbers of CD8(+) CD11a(high) cells were observed in stable and active MS and CIS. Our findings indicate that CD8(+)CD11a(high) cells play different roles in MS and NMO, and their presence may be related to the pathogenesis of MS from the early stage.
为了阐明多发性硬化症（MS）和视神经脊髓炎（NMO）的免疫学特征，我们使用流式细胞术分析了 MS（16 例稳定期，6 例活动期）和 NMO（15 例稳定期，7 例活动期）患者、9 例 NMO 谱、6 例临床孤立综合征（CIS）和 13 例其他神经疾病患者外周血中的 CD3、CD4、CD8、CD20、CD4(+)CD25(+)、CD4(+)CD29(+)和 CD8(+)CD11a(high)细胞。我们发现稳定期和活动期 MS 及 CIS 患者 CD8(+)CD11a(high)细胞数量显著减少。我们的研究结果表明，CD8(+)CD11a(high)细胞在 MS 和 NMO 中发挥不同的作用，其存在可能与 MS 的早期发病机制有关。
