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在添加激发剂的情况下,消退治疗对增强消退效果的限制。

Constraints on Enhanced Extinction Resulting from Extinction Treatment in the Presence of an Added Excitor.

作者信息

Urcelay Gonzalo P, Lipatova Olga, Miller Ralph R

机构信息

State University of New York at Binghamton.

出版信息

Learn Motiv. 2009 Nov 1;40(4):343-363. doi: 10.1016/j.lmot.2009.04.003.

Abstract

Three Pavlovian fear conditioning experiments with rats as subjects explored the effect of extinction in the presence of a concurrent excitor. Our aim was to explore this particular treatment, documented in previous studies to deepen extinction, with novel control groups to shed light on the processes involved in extinction. Relative to subjects extinguished on the target CS alone, Experiments 1 and 2 found across a range of parameters that any appreciable effect of facilitated extinction due to the concurrent excitor was submerged by generalization decrement going from extinction to testing. In Experiment 3 we used different durations for the target and concurrent stimuli in order to discourage configuring and an ABC renewal design to increase sensitivity, and observed diminished renewal resulting from extinction in the presence of a second excitor. Our findings suggest that there are distinct limits to the observation of extinction in the presence of an excitor and identifies some of the sources of these limitations.

摘要

以大鼠为实验对象进行了三项巴甫洛夫恐惧条件反射实验,探究了在同时存在一个兴奋性刺激的情况下消退的效果。我们的目的是利用新的对照组来探究这种在先前研究中被证明能加深消退的特殊处理方式,以阐明消退过程中涉及的机制。与仅在目标条件刺激上进行消退的实验对象相比,实验1和实验2发现在一系列参数条件下,由于同时存在的兴奋性刺激而导致的消退促进的任何显著效果,都被从消退到测试过程中的泛化减退所掩盖。在实验3中,我们对目标刺激和同时存在的刺激使用了不同的时长,以抑制构型形成,并采用了ABC恢复设计来提高敏感性,结果观察到在存在第二个兴奋性刺激的情况下进行消退所导致的恢复减弱。我们的研究结果表明,在存在兴奋性刺激的情况下观察消退存在明显的局限性,并确定了这些局限性的一些来源。

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