使用自适应表面跟踪方法对血细胞动态系统进行流固生化耦合模拟。
Coupled Flow-Structure-Biochemistry Simulations of Dynamic Systems of Blood Cells Using an Adaptive Surface Tracking Method.
作者信息
Hoskins M H, Kunz R F, Bistline J E, Dong C
机构信息
The Pennsylvania State University, Applied Research Laboratory, PO Box 30, State College, PA 16804.
出版信息
J Fluids Struct. 2009 Jul 1;25(5):936-953. doi: 10.1016/j.jfluidstructs.2009.02.002.
Abstract
A method for the computation of low Reynolds number dynamic blood cell systems is presented. The specific system of interest here is interaction between cancer cells and white blood cells in an experimental flow system. Fluid dynamics, structural mechanics, six-degree-of freedom motion control and surface biochemistry analysis components are coupled in the context of adaptive octree-based grid generation. Analytical and numerical verification of the quasi-steady assumption for the fluid mechanics is presented. The capabilities of the technique are demonstrated by presenting several three-dimensional cell system simulations, including the collision/interaction between a cancer cell and an endothelium adherent polymorphonuclear leukocyte (PMN) cell in a shear flow.
摘要
提出了一种用于计算低雷诺数动态血细胞系统的方法。这里感兴趣的特定系统是实验流动系统中癌细胞与白细胞之间的相互作用。在基于自适应八叉树的网格生成的背景下，将流体动力学、结构力学、六自由度运动控制和表面生物化学分析组件进行了耦合。给出了流体力学准稳态假设的解析和数值验证。通过展示几个三维细胞系统模拟，包括剪切流中癌细胞与内皮粘附多形核白细胞（PMN）细胞之间的碰撞/相互作用，证明了该技术的能力。
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