通过吲哚 - 2 - 羧酸甲酯与芳炔的[3 + 2]环化反应快速合成吲哚 - 吲哚酮骨架。
Rapid synthesis of the indole-indolone scaffold via [3+2] annulation of arynes by methyl indole-2-carboxylates.
作者信息
Rogness Donald C, Larock Richard C
机构信息
Department of Chemistry, Iowa State University, Ames, IA, 50011, U.S.A.
出版信息
Tetrahedron Lett. 2009 Jul 15;50(28):4003-4008. doi: 10.1016/j.tetlet.2009.04.047.
Abstract
The reaction of methyl indole-2-carboxylates and arynes affords a very efficient, high yielding synthesis of a novel indole-indolone ring system, which tolerates considerable functionality, is broad in scope and proceeds under mild reaction conditions.
摘要
吲哚 -2- 羧酸甲酯与芳炔的反应提供了一种非常高效、高产率的新型吲哚 - 吲哚酮环系统的合成方法，该方法能够耐受相当多的官能团，适用范围广泛，且在温和的反应条件下进行。
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