利用异腈化学通过硫介导合成衍生化的 N-连接糖肽。
Thio-mediated synthesis of derivatized N-linked glycopeptides using isonitrile chemistry.
作者信息
Wu Xiangyang, Yuan Yu, Li Xuechen, Danishefsky Samuel J
机构信息
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA.
出版信息
Tetrahedron Lett. 2009 Aug 12;50(32):4666-4669. doi: 10.1016/j.tetlet.2009.06.005.
Abstract
The reaction of oligosaccharide isonitriles with peptide thioacids in the presence of bulky thiophenol as activator to provide N-linked glycopeptides at room temperature is described.
摘要
本文描述了在室温下，寡糖异腈与肽硫代酸在大体积硫酚作为活化剂存在下反应生成N-连接糖肽的过程。
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Solid-phase peptide synthesis and solid-phase fragment coupling mediated by isonitriles.异腈介导的固相多肽合成和固相片段偶联。
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A fascinating journey into history: exploration of the world of isonitriles en route to complex amides.一段引人入胜的历史之旅：探索异腈的世界，通向复杂的酰胺。
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本文引用的文献
1
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2
Preparation and reactions of N-thioformyl peptides from amino thioacids and isonitriles.由氨基硫代酸和异腈制备N-硫甲酰基肽及其反应
Tetrahedron Lett. 2009 May 20;50(20):2329-2333. doi: 10.1016/j.tetlet.2009.02.205.
3
Addressing mechanistic issues in the coupling of isonitriles and carboxylic acids: potential routes to peptidic constructs.探讨异腈与羧酸偶联中的机理问题：形成肽类结构的潜在途径。
J Am Chem Soc. 2008 Oct 8;130(40):13225-7. doi: 10.1021/ja804709s. Epub 2008 Sep 11.
4
On the two-component microwave-mediated reaction of isonitriles with carboxylic acids: regarding alleged formimidate carboxylate mixed anhydrides.关于异腈与羧酸的双组分微波介导反应：论所谓的甲脒羧酸混合酸酐
J Am Chem Soc. 2008 Oct 8;130(40):13222-4. doi: 10.1021/ja8047078. Epub 2008 Sep 11.
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N-methylation of peptides: a new perspective in medicinal chemistry.肽的N-甲基化：药物化学的新视角。
Acc Chem Res. 2008 Oct;41(10):1331-42. doi: 10.1021/ar8000603. Epub 2008 Jul 18.
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New chemistry with old functional groups: on the reaction of isonitriles with carboxylic acids--a route to various amide types.含旧官能团的新化学：异腈与羧酸的反应——通往各类酰胺的途径
J Am Chem Soc. 2008 Apr 23;130(16):5446-8. doi: 10.1021/ja800612r. Epub 2008 Mar 28.
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