Burns Noah Z, Jessing Mikkel, Baran Phil S
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Tetrahedron. 2009 Aug 15;65(33):6600-6610. doi: 10.1016/j.tet.2009.05.075.
A full account of synthetic efforts towards the indeno-tetrahydropyridine core of haouamine A is presented. Initial failed strategies led to the unexpected discovery of a mild abnormal Chichibabin pyridine synthesis and provided knowledge and inspiration for the development of a cascade annulation that has enabled rapid and scalable access to the core in either racemic or enantiopure form.
本文全面介绍了针对豪胺A的茚并四氢吡啶核心结构的合成研究。最初失败的策略意外地促成了温和的异常齐齐巴宾吡啶合成反应的发现，并为级联环化反应的开发提供了知识和灵感，该反应能够以消旋或对映体纯的形式快速且可扩展地合成该核心结构。
