Carr Chris, Espy Michelle, Nath Pulak, Martin Sara L, Ward Michael D, Martin John
Applied Modern Physics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
J Magn Magn Mater. 2009 May;321(10):1440-1445. doi: 10.1016/j.jmmm.2009.02.064.
Our goal is to develop an instrument for parallel and multiplexed bioassay using magnetic labels. Toward this end we are developing a multi-outlet magnetophoresis instrument incorporating a fluidic flow chamber placed inside a magnetic field gradient. Magnetic microparticles are sorted by their magnetic moment for eventual use as biological labels based on magnetic signature.In this paper we concentrate on developments in our flow chamber fabrication methods that have allowed us to scale the number of sorting channels from 8 to 25. We present data for instrument performance and reproducibility of sorting.
我们的目标是开发一种使用磁性标记物进行并行和多重生物测定的仪器。为此，我们正在开发一种多出口磁泳仪器，该仪器包含一个置于磁场梯度内的流体流动腔室。磁性微粒根据其磁矩进行分类，最终用作基于磁性特征的生物标记物。在本文中，我们专注于流动腔室制造方法的进展，这些进展使我们能够将分类通道的数量从8个增加到25个。我们展示了仪器性能和分类重现性的数据。
