微波辅助直接联芳基偶联：首次应用于阿朴啡类化合物的合成
Microwave-Assisted Direct Biaryl Coupling: First Application to the Synthesis of Aporphines.
作者信息
Chaudhary Sandeep, Pecic Stevan, Legendre Onica, Harding Wayne W
机构信息
Dept. of Chemistry, Hunter College, and the Graduate Center of the City University of New York, 695 Park Avenue, New York, NY 10065, USA.
出版信息
Tetrahedron Lett. 2009 May 20;50(20):2437-2439. doi: 10.1016/j.tetlet.2009.03.029.
Abstract
We have investigated the use of microwaves in a direct biaryl coupling reaction for the synthesis of analogs of the aporphine alkaloid nantenine. Our study shows that the aporphine core may be rapidly accessed from benzyl-tetrahydroisoquinoline substrates with this method. This is the first report of a microwave-assisted direct biaryl coupling reaction in the synthesis of aporphine molecules.
摘要
我们研究了微波在直接联芳基偶联反应中用于合成阿朴菲生物碱南天竹碱类似物的应用。我们的研究表明，用这种方法可以从苄基 - 四氢异喹啉底物快速得到阿朴菲核心结构。这是关于微波辅助直接联芳基偶联反应用于合成阿朴菲分子的首次报道。
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