Yoo Byunghee, Sheth Vipul R, Pagel Mark D
Biomedical Engineering Interdisciplinary Program, The University of Arizona, Tucson AZ.
Tetrahedron Lett. 2009 Aug 5;50(31):4459-4462. doi: 10.1016/j.tetlet.2009.05.061.
An amine-derivatized DOTA has been used to modify the surface of a polymeric support for conventional Solid Phase Peptide Synthesis (SPPS) following standard Fmoc chemistry methods. This methodology was used to synthesize a peptide-DOTA conjugate that was demonstrated to be a PARACEST MRI contrast agent. Therefore, this synthesis methodology can facilitate Fmoc SPPS of molecular imaging contrast agents.
一种胺衍生化的DOTA已被用于按照标准的Fmoc化学方法修饰用于传统固相肽合成（SPPS）的聚合物载体表面。该方法用于合成一种肽-DOTA缀合物，已证明其为一种PARACEST MRI造影剂。因此，这种合成方法可促进分子成像造影剂的Fmoc SPPS。
