使用外源性磁共振成像造影剂检测酶活性。
Detecting enzyme activities with exogenous MRI contrast agents.
作者信息
Hingorani Dina V, Yoo Byunghee, Bernstein Adam S, Pagel Mark D
机构信息
Department of Chemistry and Biochemisty, University of Arizona, 1515 N. Campbell Ave., Tucson, AZ (USA).
出版信息
Chemistry. 2014 Aug 4;20(32):9840-50. doi: 10.1002/chem.201402474. Epub 2014 Jul 2.
Abstract
This review focuses on exogenous magnetic resonance imaging (MRI) contrast agents that are responsive to enzyme activity. Enzymes can catalyze a change in water access, rotational tumbling time, the proximity of a (19)F-labeled ligand, the aggregation state, the proton chemical-exchange rate between the agent and water, or the chemical shift of (19)F, (31)P, (13)C or a labile (1)H of an agent, all of which can be used to detect enzyme activity. The variety of agents attests to the creativity in developing enzyme-responsive MRI contrast agents.
摘要
本综述聚焦于对酶活性有响应的外源性磁共振成像（MRI）造影剂。酶可催化水的可及性、旋转翻滚时间、（19）F标记配体的接近程度、聚集状态、造影剂与水之间的质子化学交换速率或造影剂中（19）F、（31）P、（13）C或不稳定（1）H的化学位移发生变化，所有这些均可用于检测酶活性。这类造影剂的多样性证明了在开发酶响应性MRI造影剂方面的创造力。
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